Over the past decade, a variety of human organoids and tumor models have been established to mimic single organ (patho)physiology in standard cell culture. However, these organoids lack physiological perfusion of nutrients and inter-organ crosstalk to fully mimic human (patho)physiology in vitro. A wide range of microfluidic microphysiological multi-organ chip systems have been developed to fill this gap. They are about to revolutionise basic research in human biology, the development of curative therapies and the precision of personalised medicine. The presentation will showcase advanced human organoid-based models and assays based on TissUse's HUMIMIC® MPS technology platform targeting various healthcare challenges. Finally, it will highlight how stem cell technologies, organoid differentiation platforms and MPS-based computational modelling are converging to enable automated large-scale operation of chips reflecting patient`s systemic pathophysiology for on-chip clinical trials in the future.
From organoids to organismoids on chips – how to emulate human (patho)physiology in vitro?
Die Klinik für Urologie und Kinderurologie hat Prof. Dr. Uwe Marx aus Berlin zu einem Vortrag im Hörsaal der Urologie eingeladen.
